最新ニュース

September 6, 2017

チェコ共和国 マサリク大学でNanoWizard® AFM と ForceRobot®モジュールを使用し、 生体分子と細胞の相互作用について研究を進めているユーザーをご紹介いたします。

August 2, 2017

スコットランドグラスゴー大学でのNanoWizard AFMとCellHesionモジュールを使用した、細胞の環境に対する応答に関する研究についてご紹介します。

May 31, 2017

JPKはAbberior Instruments社と協力し、ベルリン本社内に新たにデモンストレーション施設を開設したことをお知らせします。 NanoWizard®AFM  … 

April 5, 2017

ローマカトリック大学では、JPKのNanoWizard® AFM と CellHesion®システムを使用し、細胞の機械的刺激に対する検知と応答について研究しています。

March 7, 2017

イギリスシェフィールド大学ではJPKのNanoWizard®AFMシステムが、分子スケールのソフトマターや生体システムの理解を深めるために使用されています。

次回イベント

9月4日~9日

ESB 2017 in Athens, Greece

Press releases

2017-08-02 | スコットランドグラスゴー大学でのNanoWizard AFMとCellHesionモジュールを使用した、細胞の環境に対する応答に関する研究についてご紹介します。

Professor Huabing Yin (seated) and her students with their JPK NanoWizard® AFM with the CellHesion® module at the University of Glasgow.

JPK Instruments, a world-leading manufacturer of nanoanalytic instrumentation for research in life sciences and soft matter, is pleased to report on the Yin group in the Division of Biomedical Engineering at the University of Glasgow. They are studying cells and how they react with their surroundings using JPK’s NanoWizard® AFM and CellHesion® module.

Professor Huabing Yin is a senior lecturer in the Division of Biomedical Engineering at the University of Glasgow. Her research aims to understand how a cell interacts with its surroundings at the microscale level since this process is fundamental to a vast number of applications in health care. “We take a multidisciplinary approach, developing technologies to study cells in well-controlled microenvironments that resemble key features in their native habitats. Our research converges on micro-/nanofabrication, microfluidics, and advanced microscopic and spectroscopy technologies. These allow us to develop various integrated approaches for single cell analysis, linking biological function with chemistry and the physics of a cell.”

Professor Yin describes her work with JPK’s NanoWizard® AFM. “We use our AFM to quantify physical and mechanical properties (e.g. stiffness, viscoelasticity) of cells and their associated extracellular matrix. These properties are closely linked with cell functions in physiological (e.g. growth, differentiation; McPhee et al 2010) and pathological conditions. In collaboration with scientists in the Beatson Cancer Institute, we have shown the roles of cell stiffness (Cameron et al 2015) and extracellular matrix (Hernandez-Fernaud et al 2017) in cancer invasion. We also use our CellHesion® module to quantify the interaction between living cells and extracellular matrix. This offers a great capability for dynamic monitoring of cell-matrix interaction with nanoscale resolution.”

The NanoWizard® has been particularly flexible for integration with other techniques. Professor Yin continues: “We have used various optical microscopic and spectroscopic techniques (such as Raman). We combine some of them, in particularly, fluorescence and TIRF imaging with AFM. This significantly enhances our ability to associate biological activity with the physics of cells. The JPK system is very reliable and easy to use. Our NanoWizard® AFM has been used intensively for over ten years and it has never let us down.”

 

 

 

 

 

One of Dr Yin’s students, Louise Manson, works with the JPK NanoWizard® AFM.

 

 

References

Can common adhesion molecules and microtopography affect cellular elasticity? A combined atomic force microscopy and optical study. McPhee G, Dalby MJ, Riehle M, Yin HB, Medical & Biological Engineering & Computing 48: 1043-1053 (2010).

Polarized Cell Motility Induces Hydrogen Peroxide to Inhibit Cofilin via Cysteine Oxidation. Cameron JM, Gabrielsen M, Chim YH, Munro J, McGhee EJ, Sumpton D et al., Current Biology 25: 1520-1525 (2015).

Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity. Hernandez-Fernaud JR, Ruengeler E, Casazza A, Neilson LJ, Pulleine E, Santi A et al, Nat Commun 8: 17 (2017).


For more details about JPK’s AFM systems and their applications for the materials, life & nano sciences, please contact JPK on +49 30726243 500. Alternatively, please visit the web site: www.jpk.com or see more on Facebook: www.jpk.com/facebook and on You Tube: http://www.youtube.com/jpkinstruments.

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